For Research Use Only. Not for Clinical Use.

Efficient and safe technology is essential for the development of half-life extension pharmaceuticals. Creative Biolabs is one of the well-recognized experts who are professionals in the field of half-life extension. Creative Biolabs now provides various half-life extension strategies, especially the next generation albumin-based half-life extension strategies, for our global customers.

Background of Next Generation Albumin

Albumin is the most abundant protein in the blood and plays an important role in the transport process of different endogenous, such as fatty acids, amino acids, and various drugs. Three homologous albumin domains are designated DI, DII, and DIII. The long serum half-life of albumin is due to its interaction with the neonatal Fc receptor (FcRn). FcRn is a dual binding receptor that binds albumin to protect its degradation. Moreover, albumin is characterized by solubility and stability. Based on the above reasons, albumin has been explored to produce a wide range of biopharmaceuticals.

Fig.1 Overall structure of FcRn and albumin. (Andersen, 2012)

Introduction of Next Generation Albumin

With the development of science and technology, a lot of studies are being performed to bioengineer next-generation albumins to enhance the curative effects relying on albumin. The key point of the new technology is the manipulation of the FcRn-albumin complex, which required albumin variants that have longer and shorter half-lives than natural albumin. To this end, scientists have used a structure-based approach, supported by the analysis of site-specific mutants, to identify residues involved in the binding of albumin to FcRn. Results show that both FcRn and albumin domain III in this complex allow specific molecular interactions. The development of the FcRn-albumin complex may speed up the process of novel albumin variants with altered serum half-life as carriers of drugs.

Other Serum Proteins for Half-Life Extension

In addition to albumin utilizing FcRn-mediated recycling for a longer half-life, other serum proteins have also been recognized as half-life extension modules. Serum transferrin is a typical example. Serum transferrin acts as a transporter with a half-life of 14-17 days.

Highlights of Next Generation Albumin Based Half-Life Extension Strategies

• Advanced platform and professional experts
• Efficient and safe technology
• Wide variety of half-life extension strategies
• High-quality customized solutions
• Reliable manufacturing effect and fast turnaround time

Due to our experience of half-life extension strategies, Creative Biolabs offers high-quality half-life extension services for customers all over the world. For more information, please feel free to contact us.

Reference

1. Andersen, J. T.; et al. Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor. Nature communications. 2012, 3(1): 1-9.