Resources
For Research Use Only. Not for Clinical Use.
Creative Biolabs offers a wide range of reference resources and technical materials to support half-life extension drug development, helping researchers explore innovative strategies and optimize therapeutic design. We invite you to browse our resources and accelerate your project today.
Chemical Methods for Biopharmaceutical Half-Life Extension
This article reviews innovative chemical strategies for extending the half-life of biopharmaceuticals, including XTEN mimetics, dextran conjugation, glycosylation, and lipidation, to enhance drug stability, efficacy, and patient compliance while ensuring safety and biocompatibility.
LEARN MOREPK Studies: Key to Half-Life Extension Drug Development
Pharmacokinetic studies are essential for developing half-life extension drugs, offering insights into absorption, metabolism, and clearance. Strategies include prodrugs, drug delivery systems, and enzyme modulation to improve drug stability, reduce dosing frequency, and enhance patient compliance.
LEARN MOREExtending the Half-Life of Therapeutic Proteins: The Promise of Fc-Fusion Proteins
Fc-fusion proteins enhance therapeutic protein half-life by combining IgG Fc regions with biologics, improving stability, pharmacokinetics, and efficacy. They reduce dosing frequency, support treatment of chronic diseases, and present analytical and manufacturing challenges requiring precise bioengineering.
LEARN MOREAlbumin-Binding Domain: A Promising Approach in Half-Life Extension Drug Development
Albumin extends drug half-life via FcRn recycling, reducing dosing frequency and improving pharmacokinetics. Strategies include non-covalent binding, covalent attachment, and genetic fusion, enhancing drug stability, bioavailability, and sustained therapeutic performance across various biologic formats.
LEARN MORERevolutionizing Drug Half-Life Detection with SNAP-tag Fusion Technology
SNAP-tag fusion technology enables real-time, non-invasive visualization of drug dynamics, aiding precise half-life measurement. By tracking tagged molecules, researchers optimize pharmacokinetics and refine drug design, improving stability, bioavailability, and intracellular behavior in early development stages.
LEARN MOREThe Innovative Half-life Extension and Sustained-release Drug Delivery Systems
Half-life extension and sustained-release systems improve drug efficacy by prolonging activity and reducing dosing frequency. Techniques include polymer, microsphere, lipid-based, and implantable systems, tailored for peptides, proteins, or toxic drugs requiring controlled, long-term delivery and enhanced bioavailability.
LEARN MOREExtending Drug Half-Life through PEGylation
PEGylation extends drug half-life by attaching PEG polymers to therapeutic molecules, increasing solubility, reducing renal clearance, and masking immunogenicity. This enhances pharmacokinetics, lowers dosing frequency, and improves treatment performance across peptides, proteins, and small-molecule drugs.
LEARN MORERelated Services:
- Chemical Methods for Biopharmaceutical Half-Life Extension
- PK Studies: Key to Half-Life Extension Drug Development
- Extending the Half-Life of Therapeutic Proteins: The Promise of Fc-Fusion Proteins
- Albumin-Binding Domain: A Promising Approach in Half-Life Extension Drug Development
- Revolutionizing Drug Half-Life Detection with SNAP-tag Fusion Technology
- The Innovative Half-life Extension and Sustained-release Drug Delivery Systems
- Extending Drug Half-Life through PEGylation
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For Research Use Only. Not for Clinical Use.