For Research Use Only. Not for Clinical Use.

Creative Biolabs is one of the leading experts who are professionals in extending the half-life of target drugs. The extended half-life is essential in the treatment process. Creative Biolabs provides various half-life extended services to help your projects.

Introduction of Obsessive-compulsive Disorder

Obsessive-compulsive disorder (OCD) is a frequent, chronic, costly, and disabling disorder that presents in several medical settings. Although OCD has always been seen as providing important clues for exploring the unconscious mind, it is under-recognized and undertreated. OCD has the typical characteristics of unwanted thoughts that cause anxiety or distress and behaviors. Although rituals and avoidance strategies reduce obsessional anxiety in the short term, they maintain the problem in the long run by preventing the disconfirmation of feared consequences. Persons with OCD also know these actions or thoughts were unnecessary but unable to get rid of them, if left untreated, the OCD can be a chronic condition.

Fig.1 Obsessive-compulsive disorder.

Common Behaviors of OCD

• Forced examination
• Forced washing
• Forced questioning
• Compulsive ritual actions
• Compulsive retardation

Drugs for OCD

OCD is a serious mental illness. Effective psychological and drug treatments are necessary. Several drugs are effective in the treatment of OCD, such as clomipramine and selective serotonin reuptake inhibitors (SSRIs). Clomipramine is frequently used in treating OCD. The most common SSRIs include citalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline. Compared with depression, higher doses of SSRIs may be needed to effectively treat OCD. SSRIs have superseded clomipramine due to the equivalent efficacy and better tolerability with lower toxicity for OCD.

Benefits of Extended Half-Life Drugs

studies showed that people with OCD benefit from long-term drug treatment. Like depression, sudden discontinuation of OCD can also lead to some undesirable consequences. Therefore, the extended half-life is essential in the treatment process. Compared with other commonly used drugs, fluoxetine has the advantage of a long half-life. The longer half-life of fluoxetine can protect against the breakthrough of undesirable consequences. This effect provides a new way to develop new drugs for OCD in the future.

Creative Biolabs now provides a series of methods for extending the half-life of drugs for our global customers. If you are interested in our services, please feel free to contact us.