Half-life Extension Service by Genetic Manipulation
For Research Use Only. Not for Clinical Use.
With the development of site-directed mutation of proteins, genetic engineering is used to extend the half-life of therapeutic proteins or peptides by replacing one or more key amino acids. This strategy is very simple and convenient, completely avoids the process of modification in vitro, and directly expresses the purified target protein drug molecules, which has great application potential. Creative Biolabs is always committed to providing the scientific community with the latest and most comprehensive services in the field of drug discovery. Our scientists are confident in offering the best half-life extension service by genetic manipulation for the development of novel drugs.
Introduction of Half-life Extension Service
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Antibodies, hormones, and interferons suffering from short half-life are endogenous protease degradation in vivo. However, many proteases are restriction enzymes that recognize and cut protein or at a particular site. Therefore, suitable genetic manipulation will lead to the changes in protein primary sequence and protect protein drugs from enzymolysis. Hence the amino acid mutation caused by genetic engineering can enhance the pharmacokinetic properties of the protein with maintaining its activity intact. |
Applications of Half-life Extension Service by Genetic Manipulation
Recent research has shown that mutation in one or more genes has successfully generated a few long-acting counter parts of native short-acting peptide therapeutics. Alteration of one or more amino acids in a peptide chain is used to prolong the half-life of proteins, and most of them obtained an extension of half-lives by more than ten times.
Lately, studies suggest that a single amino-acid substitution can make a molecule highly protease resistant in vivo. The point mutation of interferon has been used in long-acting interferon beta preparation. While genetic manipulation based improved somatropin formulation was entered phase 1 trial. Many achievements supported that point mutation has surfaced as a new technology for protein pharmacokinetic enhancement and is widely used in therapeutic protein research. As a novel, convenient, and one-stop half-life extension strategy, genetic manipulation bears great expectations of the drugs development market.
Highlights of Half-life Extension Service by Genetic Manipulation
- Convenient, inexpensive, and rapid.
- Free of modification in vitro.
- Suitable to most therapeutic proteins.
- Remain the natural folding of proteins.
Genetic manipulation half-life extension service shows rich research value and the application potential in protein drugs development. If you are interested in our services, or you have any questions about your drug research, please feel free to contact us for more information.
Please submit a detailed description of your project. Our industry-leading scientists will review the information provided as soon as possible. You can also send emails directly to for inquiries.
For Research Use Only. Not for Clinical Use.