Drug Half-Life In Vivo Detection Services
For Research Use Only. Not for Clinical Use.
Therapeutic proteins are used for a range of disorders, because of their higher potency, selectivity and safety over small molecules, the number of new protein drugs entering clinical trials continues to grow. Nowadays, many studies were conducted to improve therapeutic proteins potency by extending their half-life. Therefore, a simple and accurate way to measure target proteins half-life in vivo is necessary and useful to predict the pharmacokinetic properties in clinic trial. Based on rich experience and established platform in protein research field, Creative Biolabs has developed different drug half-life in vivo detection services to meet the unique requirements of every client. Moreover, we can screen and optimize the target protein molecules according to the half-life measurements and eventually obtain the most potential structure for commercialization.
Introduction of Drug Half-Life In Vivo Detection Services
Since the approval of the first monoclonal antibody in 1986, there has been a rapid increase in the number of available monoclonal antibodies or antibody derivatives. Although antibodies and Fc-fusion antibody-like proteins have become successful biologics, most of them suffer from poor pharmaceutical properties and short half-life. Therefore, many strategies for enhancing the in vivo half-life of proteins have been reported to improve their potency. However, due to complex mechanisms of interaction with the immune system, it is difficult to accurately determine the exogenous proteins half-life in vivo compared with small molecule drugs or in vitro, such as antibodies and hormones.
With the development of protein engineering and animal science, various methods have been developed for half-life in vivo detection. These new development methods mostly focus on two main directions: more intuitive and accurate determination of protein drugs concentration in vivo and more hominine metabolism system of extrinsic protein drugs. Various of radioactive or fluorescent labels were attached to proteins molecules, which provides an approach to track the distribution of drugs and assay the protein concentration in vivo. For another, many humanized transgenic mouse strains or other humanoid animals have been used in drug half-life in vivo detection.
Custom Services of Drug Half-Life In Vivo Detection
Creative Biolabs provides multifarious approaches to develop drug half-life in vivo detection platform maturely and rapidly.
SNAP-tag is a self-labeling tag that particularly well suited for measuring in vivo protein half-life through chemical labeling. By this tag, target proteins can be modified by various fluorescent groups, which enable to visualize them by imaging methods and determine target protein drugs half-life in vivo.
Animal models have provided an important tool to help make the decision to take potential therapies from preclinical studies to humans. Therefore, more humanoid animal models reflect the truer half-life of drugs in humans. The establishment of such animal models requires transgenic operation.
If you are interested in any one of our drug half-life in vivo detection services, or you have any questions about your drug research, please feel free to contact us for more information.
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For Research Use Only. Not for Clinical Use.