Nanoparticle (NP) Based Sustained Release Drug Delivery System
For Research Use Only. Not for Clinical Use.
The use of nanoparticle (NP) mediated drug delivery to modulate pharmacokinetic and pharmacodynamics of a therapeutic is a proven approach to create long-acting therapeutic formulations, which was generally accepted in the field of new drug development owing to its safety and flexibility. As a sustained release drug delivery system development service provider with decades of experience, Creative Biolabs has established perfect platforms and provides mature nanoparticle encapsulated drug delivery technology.
Introduction of Nanoparticle (NP) Based Sustained Release Drug Delivery System
Instead of modifying the pharmacokinetics of a therapeutic molecule in a conventional sense, NP based sustained release drug delivery system relies on incorporating protein or small molecule drugs in a matrix carrier that works like a protective covering for it. This system works like a depot and instead of introducing the therapeutic amount all at a time, this releases the drug to systemic circulation slowly creating a long-acting formulation. Therefore, carriers are designed in a way that will protect the protein molecule from enzymatic degradation, keep its biological activity unaltered while increasing absorption to the systemic circulation. Moreover, these NP carriers are effective for both water soluble and insoluble proteins therapeutics avoiding extra modification, which guarantees the convenience and simpleness of NP-based sustained release drug delivery system.
Fig.1 NP based drug delivery system. (Wang, 2019)
Applications of Nanoparticle (NP) Based Sustained Release Drug Delivery System
NP-based sustained drug delivery vehicles are designed for various purposes, like, targeted delivery of a drug to a specific organ, or to protect a therapeutic from degradation in an environment that is harsh for it. These goals can be achieved by modifying the nanoparticle matrix, which is why NP modification is popular in sustained release drug research.
A popular NP-based sustained drug delivery system is PLGA (Poly-Lactic-Co-Glycolic Acid), while a few very promising PLGA and modified PLGA formulations of therapeutic proteins are in a pre-clinical or clinical trial stage. Numerous studies suggest that NP-mediated drug delivery has a significant effect on both improvements of potency and prolongation of activity. In addition, immunogenic reaction of NP attached drugs is not higher than the common formulation, which promises safety in clinic tests.
Fig.2 SEM micrography of PLGA NP. (Pool, 2012)
Highlights of NP Based Sustained Release Drug Delivery System
- Mature, stable, and widely used in the market.
- Conveniently and rapidly.
- Various nanoparticle matrix materials can be chosen to suit target proteins.
- High safety and low immunogenicity.
With more and more applications in approved therapeutic proteins, NP-based sustained release drug delivery systems are considered as a potential method to overcome the shortage in the pharmaceutical properties of protein drugs. For more details about our nanoparticle-based sustained release drug delivery system development services, please feel free to contact us.
References
- Wang, W.; et al. Nano-drug delivery systems in wound treatment and skin regeneration. Journal of nanobiotechnology. 2019, 17(1), 1-15.
- Pool, H.; et al. Antioxidant effects of quercetin and catechin encapsulated into PLGA nanoparticles. J Nanomater. 2012, 1-12.
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For Research Use Only. Not for Clinical Use.