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With the development of materials research, microspheres gradually become a kind of biocompatible protein drugs carriers, while microsphere based sustained release drug delivery system also deserves a place in the area of therapeutic molecules optimization research. Moreover, the diversity and flexibility of microsphere matrix also provide unlimited possibilities for future drug delivery system development. Based on our rich experience and pursuit of details, Creative Biolabs possesses mature microsphere production technology to offer the microsphere based sustained release drug delivery system development service rapidly and inexpensively.

Introduction of Microsphere Based Sustained Release Drug Delivery System

In the past couple of decades, there has been a significant advancement in the preparation and application of various kinds of microspheres. Some biodegradable microspheres were accepted as suitable carriers used in sustained release drug delivery system due to their special physicochemical properties, high encapsulation efficiency, and controlled drug release kinetics.

In the microsphere-based drug delivery system, microspheres loading drug molecules act as a drug depot, sustained releasing drugs to control the concentrations in the body, prolonging the half-life of drugs, and thus creating long-acting formulations. The rate of drug release is determined by the properties of the microsphere matrix, such as specific surface area, density, diameter, etc. Therefore, the key point to improve the potency is choosing the suitable microspheres matrix to match the properties of drugs.

Fig.1 Schematic illustration of MS-BNP Fabrication. (Xu, 2020)

Applications of Microsphere Based Sustained Release Drug Delivery System

Fig.2 SEM micro image of porous microspheres. (Cai, 2013)

Recent advances have resulted in the development of various types of microspheres to serve different purposes such as magnetic, double-walled, muco-adhesive, and floating ones. There are several protein-loaded microspheres as well as several small-molecule microspheres that have been approved for use as depot formulations to release drugs over long periods of time, from weeks to months. In addition, some mature microspheres products have been marketed as general-purpose therapeutic protein carriers, providing a universal way to develop microsphere-based drug delivery systems.

Remarkably, porous microspheres occupy an important place in the microsphere based sustained release drug delivery system due to their large specific surface area and low density. Protein molecules can be absorbed by porous structures, which promises a high drug loading amount can be achieved. Moreover, porous microspheres can mediate unique pulmonary delivery systems of therapeutic macromolecules as a non-invasive alternative for protein delivery.

Highlights of Microsphere Based Sustained Release Drug Delivery System

• Flexible and diverse microsphere matrix.
• Generally suitable to most proteins.
• Conveniently and rapidly.
• Unique release properties.

Microsphere based sustained release drug delivery system takes advantage of materials science and protein engineering to control the release kinetics, which has shown great potential in large-scale applications. For more details about our services, please directly contact us.

References

1. Xu, Y.; et al. Metabolism Balance Regulation via Antagonist‐Functionalized Injectable Microsphere for Nucleus Pulposus Regeneration. Advanced Functional Materials. 2020, 30(52), 2006333.
2. Cai, Y.; et al. Porous microsphere and its applications. International journal of nanomedicine. 2013, 8,1111-1120.